Great glacier(Ice Age) happened in Pleistocene Epoch, many mammals extinct around this age.
Pleistocene Epoch is sometimes called the Age of Man because the earliest humans are believed to have evolved then.
During the Holocene Epoch, beginning about 10,000 years ago, melting ice caused the sea level to rise a hundred feet or more, drowning large areas of land and broadening the continental shelf of eastern North America.
Modern man evolved, and get involved in evolution of some animals like dog evolve from wolf.
Modern man dominant, and develop technology. Also, the extinction of organisms speed up, the fourth mass extinction event begin.